Who discovered aripiprazole?
Otsuka Pharmaceutical
Aripiprazole was discovered by scientists at Otsuka Pharmaceutical and was called OPC-14597. It was first published in 1995. Otsuka initially developed the drug, and partnered with Bristol-Myers Squibb (BMS) in 1999 to complete development, obtain approvals, and market aripiprazole.
Is aripiprazole successful?
It has been shown to be effective in reducing the symptoms of schizophrenia, but can bring about serious side effects, including heart failure, weight gain, and diabetes. Aripiprazole, an atypical antipsychotic medication, has been shown to have fewer side effects than older antipsychotic drugs.
What is unique about Abilify?
Aripiprazole has a unique pharmacologic profile that includes partial agonism at several G-protein coupled receptors (GPCRs) [especially dopamine (D2) and 5-HT1A] and antagonistic action at others (especially 5-HT2A).
What is the 1 2 life of aripiprazole?
The mean elimination half-lives for aripiprazole are approximately 75 hours in extensive metabolisers of CYP2D6 and approximately 146 hours in poor metabolisers of CYP2D6.
Is Abilify and aripiprazole the same?
Abilify was first approved by the FDA to treat schizophrenia in 2002. Is there a generic version of Abilify? Yes, the generic name for the medication is aripiprazole and is available for purchase in the United States.
Is 2mg of Abilify a lot?
Adults. The recommended starting dose for ABILIFY as adjunctive treatment for patients already taking an antidepressant is 2 to 5 mg/day. The recommended dosage range is 2 to 15 mg/day. Dosage adjustments of up to 5 mg/day should occur gradually, at intervals of no less than 1 week [see Clinical Studies].
Does aripiprazole help with anxiety?
Clinical studies demonstrate that aripiprazole may be useful in the treatment of bipolar depression, major depressive disorder, treatment-resistant depression and possibly anxiety disorders. Clinical data also suggest that aripiprazole may have a lower adverse effect burden than the other atypical drugs.
Can aripiprazole cause weight gain?
Common Abilify (aripiprazole) side effects include nausea, vomiting, headache, insomnia and weight gain.