What is IL-2 and what is its role in immunity?
IL-2 has an immunoregulatory role; it promotes the growth and development of peripheral immune cells in the initiation of the (defensive) immune response, and keeps them alive as effector cells. However, later in the response it has a pro-apoptotic effect.
What are potential adverse events of interleukin 2 Select all that apply?
IL-2 can be used as a single drug treatment for these cancers, or it can be combined with chemotherapy or with other cytokines such as interferon-alfa. Side effects of IL-2 can include flu-like symptoms such as chills, fever, fatigue, and confusion. Some have nausea, vomiting, or diarrhea.
How is interleukin2 administered?
“Low-dose interleukin-2” is administered on an outpatient basis. Low-dose interleukin-2 is usually given as a shot under the skin (subcutaneous injection, SubQ). In some situations, patients may be able to give themselves these injections at home.
Is IL-2 a lymphokine?
Interleukin-2 (IL-2) plays a central role in the activation and proliferation of lymphocytes that have been primed by antigens.
What is an IL-2 inhibitor?
Compounds such as cyclosporin A (CsA), rapamycin and FK506 from microbial sources are mainly used to combat transplant rejection. Several compounds, including leflunomide and mycophenolate mofetil were developed to selectively inhibit nucleotide synthesis in T-cells and hence block IL-2 synthesis.
What does IL-2 do for T cells?
IL-2 enhances activation-induced cell death (AICD). IL-2 also promotes the differentiation of T cells into effector T cells and into memory T cells when the initial T cell is also stimulated by an antigen, thus helping the body fight off infections.
Who discovered IL-2?
Morgan et al.
Interleukin 2 (IL2) was discovered by Morgan et al. in 1976. Since then its unique functional property which induces the in vitro growth of antigen-stimulated T cells, especially cytotoxic T cells (CTL) opened a way to establish the T cell clone and gave us a way to explore the nature of T cell receptor molecule.