Is Reninoma cancerous?
They are typically diagnosed in adolescents and young adults with occasional cases reported in younger children (6–9). There is a mild female to male predominance with a ratio 1.8:1 (7). Reninomas are benign tumors with only one reported malignant case (10).
How is Reninoma treated?
Surgical resection is the major treatment modality for reninoma, because of its benign course; only 1 case was reported as recurred after initial mass resection [3,4]. JCT can be treated with a nephron-sparing partial nephrectomy (as was performed in our patient) because these tumors are usually superficially located.
What causes Reninoma?
Reninomas are benign tumors originating from the cells of the juxtaglomerular apparatus. They produce excessive amounts of renin, leading to secondary hyperaldosteronism. As a consequence of this hormonal activation, patients develop severe hypertension, potassium wasting, and hypokalemia.
What happens if the kidney produces too much renin?
12) Reninoma. Reninomas are rare tumors of the kidney cells that make renin (juxtaglomerular cell tumors). They produce excessive amounts of renin, resulting in severe hypertension, high aldosterone levels, and low blood potassium levels [22, 23].
What does macula densa sense?
Macula densa cells can sense variations in tubular fluid composition, including salt content and metabolites such as succinate. Salt is sensed via the NKCC2 and NHE2, whereas tubular succinate triggers the metabolic receptor GPR91 at the luminal plasma membrane.
What causes high renin levels?
A high level of renin may be due to: Adrenal glands that do not make enough hormones (Addison disease or other adrenal gland insufficiency) Bleeding (hemorrhage) Heart failure.
How is high renin hypertension treated?
Renal hypertension (high renin/high aldosterone) is best treated with angiotensin receptor antagonists; primary aldosteronism (low renin/high aldosterone) is best treated with aldosterone antagonists (spironolactone or eplerenone); and hypertension due to overactivity of the renal epithelial sodium channel (low renin/ …
What causes high levels of renin?
How do you reduce renin naturally?
A diet rich in fruits, vegetables and low-fat dairy products, and reduced in saturated fat, total fat and cholesterol (the ‘DASH’ diet) significantly lowers blood pressure (BP). Previous studies have documented that certain therapies that lower BP increase plasma renin activity (PRA).