What are CREB proteins?
The cAMP-response element binding protein (CREB) is an intracellular protein that regulates the expression of genes that are important in dopaminergic neurons. Dopamine affects the phosphorylation of CREB via G protein-coupled receptors.
What is the function of CREB?
CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element.
How does CREB regulate transcription?
CREB mediates the activation of cAMP-responsive genes by binding as a dimer to a conserved cAMP-responsive element (CRE), TGACGTCA3,4,5. Phosphorylation of CREB at Ser133 promotes recruitment of the transcriptional co-activator CBP and its PARALOGUE p300 (Fig.
What is CREB and its function and how does it mediated various signals?
CREB acts through calcium and the protein kinase A pathway in the corticostriatal region (a component of the central nervous system that plays a major role in learning). This process is mediated by glutamate and DA signals. Drugs that antagonize the actions of NMDA and/or DA D1 also inhibit the generation of CREB.
Is CREB a coactivator?
The transcription factor CREB binds to a DNA element known as the cAMP-regulated enhancer (CRE). Consistent with its role as a coactivator, CBP augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes.
What is the CREB pathway?
CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes.
Is CREB an activator?
Recent studies indicate that CREB functions in concert with a family of latent cytoplasmic co-activators called cAMP-regulated transcriptional co-activators (CRTCs), which are activated through dephosphorylation.
Is CREB phosphorylated by PKA?
CREB is phosphorylated on Ser133 by PKA (protein kinase A), promoting the recruitment of the co-activator proteins CBP (CREB-binding protein) and p300; this has been proposed to increase the transcription of CREB-dependent genes.
What is CREB pathway?
Is Cre a transcription factor?
CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB proteins are expressed in many animals, including humans.