What does a low renin level mean?
A low level of renin may be due to: Adrenal glands that release too much aldosterone hormone (hyperaldosteronism) High blood pressure that is salt-sensitive. Treatment with antidiuretic hormone (ADH) Treatment with steroid medicines that cause the body to retain salt.
What is a normal aldosterone to renin ratio?
In healthy volunteers, the range of the ARR (ng/dl per μg/l/h) is 2–17 with a mean of 5.5 (50–470, mean 150 when aldosterone is expressed as pmol/l). Others report higher values in healthy volunteers but usually ARR not exceeding 21–34 (amounting to a ratio of 580–940 when plasma aldosterone is expressed as pmol/l).
What causes renin suppression?
First, factors than can reversibly suppress renin include, increased intra-vascular volume, certain medications (see below), supine posture, menstrual phase and high dietary sodium intake, and therefore must all be considered [16,90,91].
What causes low renin and low aldosterone?
Third, a low-renin/low aldosterone status may result from a marked reduction in nephron number and function. These conditions include diabetic nephropathy, chronic glomerulonephritis, congenital solitary kidney, unilateral nephrectomy or ageing.
Why is renin low in primary hyperaldosteronism?
Primary hyperaldosteronism is characterized by high plasma and urinary aldosterone and suppressed PRA. Renin suppression is due to aldosterone-dependent sodium retention and mild extracellular volume expansion.
Is low renin a problem?
Patients with LREH may have a lower risk of cardiovascular disease than hypertensive patients with normal or high renin levels. Low renin levels are seen in essential hypertension as there is a higher perfusion pressure at the juxta glomerular cells which suppresses renin release.
What does low renin and low aldosterone mean?
Most often, your renin test results will be compared with aldosterone test results. These results may show one of the following: Lower than normal renin/Lower than normal aldosterone. This may mean you have Cushing’s syndrome, a disorder in which the adrenal glands make too much of a hormone called cortisol.
What is a low level of aldosterone?
Low aldosterone levels are found in a rare condition called Addison’s disease. In Addison’s disease, there is a general loss of adrenal function resulting in low blood pressure, lethargy and an increase in potassium levels in the blood (see the article on Addison’s disease for further information).
How is low renin treated?
Renal hypertension (high renin/high aldosterone) is best treated with angiotensin receptor antagonists; primary aldosteronism (low renin/high aldosterone) is best treated with aldosterone antagonists (spironolactone or eplerenone); and hypertension due to overactivity of the renal epithelial sodium channel (low renin/ …