Is triazole nucleophilic?
1 Unusual nucleophilic displacement with 1,2,3-triazole.
Which anti fungal drug contains triazole heterocyclic ring?
Various marketed antifungal therapeutics contain triazole moiety such as fluconazole, voriconazole, ravuconazole, and terconazole (Fig. 9.3).
What is a triazole fungicide?
As a broad-spectrum triazole fungicide, it is used for control of ascomycetes, fungi imperfecti, and basidiomycetes on a wide variety of crops.
Which of the following contains triazole?
Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole.
What does a triazole ring do?
Vicinal diaryl triazoles are widely studied for their medicinal properties. They possess a variety of biological and pharmacological properties such as anticancer, anti-inflammatory, COX inhibitory, anti-obesity, antiviral, and antibacterial activity.
Is ketoconazole a triazole?
Triazole antifungals: fluconazole, itraconazole, posaconazole, voriconazole. Imidazole antifungals: clotrimazole, econazole, miconazole, ketoconazole and tioconazole. Polyene antifungals: amphotericin, nystatin.
Which of the following contain triazole?
For example, antifungal drugs containing the triazole ring include the following: (1) itraconazole, (2) fluconazole, (3) voriconazole, (4) [10] the anti-viral drug ribavirin, and (5) mubritinib (used for breast, bladder, kidney, and prostate cancers) (Fig.
Which of the following is a triazole?
Currently triazole drugs (fluconazole, itraconazole, voriconazole and posaconazole) are most frequently used antifungals in clinical therapy. They possess a broad spectrum of activity and reduced toxicity when compared with imidazole antifungals [21. Current and emerging azole antifungal agents.
Is triazole a functional group?
The reaction has been widely used in bioorthogonal chemistry and in organic synthesis. Triazoles are relatively stable functional groups and triazole linkages can be used in a variety of applications, e.g. replacing the phosphate backbone of DNA.