What is Binet stage A CLL?
The Binet staging system for CLL has 3 stages: stage A – you have fewer than 3 groups of swollen (enlarged) lymph nodes. stage B – you have 3 or more groups of enlarged lymph nodes. stage C – you have a low number of red blood cells or platelets.
Can CLL be staged?
Doctors use staging to help them predict chronic lymphocytic leukemia’s (CLL’s) progression and develop an appropriate treatment plan. Two staging systems, the Rai system and the Binet System, have been used throughout the world.
How do you know if CLL is progressing?
If you start having symptoms of CLL progression, such as unexplained weight loss, fever, night sweats, swollen lymph nodes, and significant fatigue, schedule an appointment with your oncologist or hematologist right away.
What does Stage 3 CLL mean?
Stage III: The patient has lymphocytosis and anemia. The patient may or may not have swollen lymph nodes and an enlarged liver or spleen. Stage IV: The patient has lymphocytosis and low levels of platelets. The patient may or may not have swollen lymph nodes, an enlarged liver or spleen, or anemia.
Can CLL metastasize?
Bone metastasis in CLL/SLL is very rare, generally osteolytic, and affects less than 5% of CLL patients [6–9].
What are the last stages of CLL?
When the disease moves into the later stages, CLL cells crowd out the healthy cells in the bone marrow, which could lead to problems such as anemia, low platelets, and an enlarged liver and spleen.
How long can you live with Stage 4 CLL?
Median survival
| Staging system | Stage | Median survival |
|---|---|---|
| 1 and 2 | 7 years | |
| 3 and 4 | 1.5 years | |
| Binet | A | More than 10 years |
| B | 5–7 years |
Can CLL turn into AML?
Acute myeloid leukemia (AML) is another rare complication in patients who have been treated for CLL. Drugs such as chlorambucil and cyclophosphamide can damage the DNA of blood-forming cells. These damaged cells may go on to become cancer, leading to AML, which is very aggressive and often hard to treat.