What is men2a syndrome?
A rare, genetic disorder that affects the endocrine glands and causes a type of thyroid cancer called medullary thyroid cancer, pheochromocytoma, and parathyroid gland cancer. It may also cause benign (noncancerous) tumors in the parathyroid glands and adrenal glands.
What are the signs and symptoms of MEN1?
Symptoms include tiredness, depression, stomach ulcers, abdominal pain and non-specific aches and pains, and if left untreated, it can result in thinning of bones (osteoporosis) and kidney stones. Very rarely, patients with MEN1 may have a parathyroid cancer.
How do they test for MEN1?
Mayo Clinic offers a variety of advanced diagnostic tests for MEN-1. Imaging tests may include magnetic resonance imaging (MRI), computerized tomography (CT) scan, positron emission tomography (PET) scan, nuclear medicine scans, endoscopic ultrasound of the pancreas and other scans.
What is mens1?
Overview. Multiple endocrine neoplasia, type 1 (MEN 1), sometimes called Wermer’s syndrome, is a rare disorder that causes tumors in the endocrine glands and parts of the small intestine and stomach.
What is the most common cause of multiple endocrine neoplasia?
Multiple endocrine neoplasia type 4 appears to have signs and symptoms similar to those of type 1, although it is caused by mutations in a different gene. Hyperparathyroidism is the most common feature, followed by tumors of the pituitary gland, additional endocrine glands, and other organs.
What is Sipple syndrome?
Listen to pronunciation. (SIH-pul SIN-drome) A rare, genetic disorder that affects the endocrine glands and causes a type of thyroid cancer called medullary thyroid cancer, pheochromocytoma, and parathyroid gland cancer.
Is multiple endocrine neoplasia a rare disease?
Multiple endocrine neoplasia type 2 (MEN type 2) is a rare genetic disorder characterized by tissue overgrowth or tumor formation in various endocrine glands including the thyroid, the adrenal glands and the parathyroid.
What are multiple endocrine neoplasia syndromes?
Multiple endocrine neoplasia syndromes are rare, inherited disorders in which several endocrine glands develop noncancerous (benign) or cancerous (malignant) tumors or grow excessively without forming tumors.
What causes endocrine neoplasia syndromes?
The tumors and the abnormally large glands often produce excess hormones. Although tumors or abnormal growth may occur in more than one gland at the same time, changes often take place over time. Multiple endocrine neoplasia syndromes are caused by inherited genetic mutations. A single gene responsible for type 1 disease has been identified.
How does multiple endocrine neoplasia type 1 affect the body?
Almost all people with multiple endocrine neoplasia type 1 have tumors of the parathyroid glands. Most of the tumors are noncancerous, but they cause the glands to produce too much parathyroid hormone ( primary hyperparathyroidism Hyperparathyroidism In hypercalcemia, the level of calcium in blood is too high.
Do endocrine neoplasia syndromes run in families?
Multiple endocrine neoplasia syndromes are caused by gene mutations, so they tend to run in families. Symptoms vary depending on which glands are affected. Genetic screening tests can be done to detect disease in family members of people who have multiple endocrine neoplasia syndromes.