What is TCF in biology?
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are multifunctional proteins that use their sequence-specific DNA-binding and context-dependent interactions to specify which genes will be regulated by Wnts.
What does ETS transcription factor do?
Function. The ETS family is present throughout the body and is involved in a wide variety of functions including the regulation of cellular differentiation, cell cycle control, cell migration, cell proliferation, apoptosis (programmed cell death) and angiogenesis.
What are specific transcription factors?
Transcription factors are proteins that are required to initiate or regulate gene transcription in eukaryotic cells. Specific transcription factors stimulate or repress transcription of particular genes by binding to their coordinate regulatory sequence which promotes or blocks RNA polymerase binding respectively.
What is TCF gene?
The TCF/LEF family (T cell factor/lymphoid enhancer factor family) is a group of genes that encode transcription factors which bind to DNA through a SOX-like high mobility group domain. TCF/LEF factors recruit the coactivator beta-catenin to enhancer elements of genes they target.
What is ETS domain?
The ETS domain identifies all Ets proteins as sequence-specific DNA-binding proteins. This motif, composed of 85 amino acids, forms a winged helix–turn–helix tertiary structure, which allows Ets proteins to interact with an approximately 10 bp long DNA element containing a GGAA/T central core.
What is ETS fusion?
The fusion of the genes ERG and TMPRSS2 is the most frequent genomic alteration in prostate cancer. ERG is an oncogene that encodes a member of the family of ETS transcription factors. At lower frequency, other members of this gene family are also rearranged and overexpressed in prostate cancer.
What are transcription factors How do they affect transcription?
Transcription factors are proteins that help turn specific genes “on” or “off” by binding to nearby DNA. Transcription factors that are activators boost a gene’s transcription. Repressors decrease transcription.
How many transcription factors are there?
Approximately 1,500 transcription factors (TFs) are encoded in the mammalian genome1 and constitute the second largest gene family, with the immunoglobulin superfamily being the largest.