What is Type 2 von Willebrand disease?
Disease definition. A form of von Willebrand disease (VWD) characterized by a bleeding disorder associated with a qualitative deficiency and functional anomalies of the Willebrand factor (VWF).
How many types of von Willebrand disease are there?
Although VWD occurs among men and women equally, women are more likely to notice the symptoms because of heavy or abnormal bleeding during their menstrual periods and after childbirth. There are 3 major types of VWD: Type 1, Type 2, and Type 3.
What is Type 3 von Willebrand disease?
type 3 – the most severe and rarest type. People with type 3 VWD have very low levels of von Willebrand factor, or none at all. Bleeding from the mouth, nose and gut is common, and you can have joint and muscle bleeds after an injury.
Can you take ibuprofen with von Willebrand disease?
Treatment depends on the type of von Willebrand’s disease you have, how much you bleed, and your risk for heavy bleeding. You may need to: Avoid nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen (Advil or Motrin, for example), and naproxen (Aleve).
What is another name for von Willebrand’s disease?
Platelet-type von Willebrand disease (PT-VWD), also known as pseudo-von Willebrand disease, is an extremely rare genetic disorder characterized by prolonged bleeding time.
What factor is VWF?
von Willebrand factor (VWF) is a large adhesive glycoprotein required for platelet adhesion to subendothelium at the site of vessel injury, platelet aggregation to form the platelet plug, and stabilization of factor VIII (FVIII) in the circulation. Deficiency or defect of VWF leads to von Willebrand disease (VWD).
What is von Willebrand factor 8?
Von Willebrand factor is involved in the early stages of blood clotting, and also carries the important clotting protein factor VIII. In people with VWD, the amount of Von Willebrand factor clotting protein in the blood is lower than normal or doesn’t work as it should.
Can you get blood clots if you have von Willebrand’s?
People with von Willebrand’s disease either lack, or have ineffective supplies of, a substance in the blood called von Willebrand factor (vWF). This promotes clotting. People with the condition will have difficulty forming blood clots. For example, if they cut themselves, it will take longer to stop bleeding.
Does VWF activate platelets?
VWF is a large multimeric plasma glycoprotein synthesized by megakaryocytes and endothelial cells. It plays a key role in the adhesion of platelets to exposed subendothelium, mediates shear-dependent activation of platelets, and increases thrombin generation on the platelet procoagulant surface (22–26).