What is HbS beta thalassemia?
Sickle beta thalassemia is an inherited condition that affects hemoglobin, the protein in red blood cells that carries oxygen to different parts of the body. It is a type of sickle cell disease.
Is beta thalassemia similar to sickle cell?
It is a type of sickle cell disease. Affected people have a different change ( mutation ) in each copy of their HBB gene : one that causes red blood cells to form a “sickle” or crescent shape and a second that is associated with beta thalassemia, a blood disorder that reduces the production of hemoglobin.
What is beta thalassemia trait?
Beta thalassemia is an inherited blood disorder in which the body doesn’t make hemoglobin normally. Hemoglobin is the part of red blood cells (RBCs) that carries oxygen throughout the body. The abnormal hemoglobin can lead to anemia (not enough RBCs in the body) and other medical problems.
What is sickle cell thalassemia beta zero?
When a person has one copy of Hb-S and one copy of beta thalassemia, it is called sickle beta zero thalassemia. Sickle beta zero thalassemia (THAL-UH-SEE-ME-AH) is a blood condition that is similar to sickle cell anemia. Sickle cell anemia is a disease that causes red blood cells (RBCs) to have an abnormal shape.
How common is sickle cell and beta thalassemia?
Sickle cell disease (SCD) and β-thalassemia are among the most common inherited diseases, affecting millions of persons globally. It is estimated that 5-7% of the world’s population is a carrier of a significant hemoglobin variant.
What is sickle beta plus thalassemia?
Sickle beta plus thalassemia (HbS β+thal) is a mild form of sickle cell disease. Many babies with HbS β+thal are born healthy and do not show symptoms until later in childhood. Some problems can include low red blood cell count, pain, and risk of infection.
What is the difference between alpha thalassemia and beta thalassemia?
When thalassemia is called “alpha” or “beta,” this refers to the part of hemoglobin that isn’t being made. If either the alpha or beta part is not made, there aren’t enough building blocks to make normal amounts of hemoglobin. Low alpha is called alpha thalassemia. Low beta is called beta thalassemia.
Why is beta thalassemia more common?
The beta thalassemia syndromes are much more diverse than the alpha thalassemia syndromes due to the diversity of the mutations that produce the defects in the beta globin gene.
What is difference between anemia and thalassemia?
Anemia is a condition in which your body doesn’t have enough normal, healthy red blood cells. Thalassemia is inherited, meaning that at least one of your parents must be a carrier of the disorder. It’s caused by either a genetic mutation or a deletion of certain key gene fragments.
How does beta thalassemia affect hemoglobin?
Beta thalassemia is a blood disorder that reduces the production of hemoglobin . Hemoglobin is the iron-containing protein in red blood cells that carries oxygen to cells throughout the body. In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body.